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                                Colloquium Schedule | Upcoming Events

                                1. CATALYTIC CO2 REDUCTION BY PALLADIUM
                                  DECORATED SILICON HYDRIDE NANOSHEETS
                                  The Ozin Group shows how decorating silicon nonosheets with palladium
                                  nanoparticles renders the process catalytic, a breakthrough with far
                                  reaching technological implications.
                                  Ozin group, Nature Catalysis, 2019
                                2. UNUSUAL REARRANGEMENT OF AN
                                  N-DONOR-FUNCTIONALIZED N-HETEROCYCLIC
                                  CARBENE LIGAND ON GROUP 8 METALS
                                  The Song group discovered an unusual rearrangement reaction,where
                                  the N,C-chelate ligand of a piano-stool Group 8complex isomerizes into
                                  an N,N-chelate ligand. Mechanistic study suggests the involvement of a
                                  high-energy metal-alkylidene intermediate.
                                  Song group, Journal of the American Chemical Society, 2018
                                3. DYSREGULATION OF MITOCHONDRIAL CLPP
                                  PROTEASE AS A POTENTIAL STRATEGY TO
                                  DEVELOP NOVEL ANTICANCERS
                                  Human mitochondrial ClpP was found to be activated by specific
                                  acyldepsipeptide compounds causing apoptotic cell death.
                                  Houry and Batey groups, Cell Chemical Biology, 2018
                                4. AMINE HEMILABILITY ENABLES BORON TO
                                  MECHANISTICALLY RESEMBLE EITHER
                                  HYDRIDE OR PROTON
                                  Mechanistic studies of the hemilability of MIDA
                                  (N-methyliminodiacetic acid) boronates reveal the chameleonic
                                  behaviour of the BMIDA group.
                                  Yudin group, Nature Chemistry, 2018
                                5. TIPPING CELL SIGNALING PATHWAYS BY SALTS
                                  Mechanistic insights into allosteric regulation ofthe A2A adenosine
                                  G protein-coupled receptor byphysiological cations.
                                  Prosser group, Nature Communications, 2018
                                6. COMPETITIVE SELF-ASSEMBLY KINETICS AS A
                                  ROUTE TO CONTROLLING MORPHOLOGY OF
                                  CORE-CRYSTALLINE CYLINDRICAL MICELLESS
                                  One can manipulate the seeded-growth kinetics of block
                                  copolymer unimers to control the growth sequence of
                                  unimers and thus the comicelle morphology.
                                  Winnik group, Journal of the American Chemical Society, 2018
                                7. INHIBITING MYC BINDING TO THE E-BOX DNA
                                  MOTIF BY ME47 DECREASES
                                  TUMOUR XENOGRAFT GROWTH
                                  The Shin lab's designed protein ME47 decreased tumor growth in
                                  a triple negative breast cancer mouse model, a type of cancer with
                                  no effective treatments.
                                  Shin, Chan & Penn groups, Oncogene, 2017


                                Professor Artur Izmaylov wins JPC-PHYS Lectureship award

                                Congratulations to Professor Artur Izmaylov for winning a 2019 Journal of Physical Chemistry-PHYS Lectureship Award. The JPC-PHYS lectureship awards honour the contributions of investigators who have made major impacts in their field of physical chemistry.

                                Prof. Izmaylov is the first winner of this award from U of T. The lecture and award will be presented at the American Chemical Society meeting in August.

                                News and Announcements:

                                Professor Aaron Wheeler receives $3m Genome Canada grant

                                Professor Aaron Wheeler receives $3m Genome Canada grant

                                Kirsty Duncan, Minister of Science and Sport, announced today the funding recipients from Genome Canada’s Disruptive Innovations in Genomics.

                                Professor Aaron Wheeler will receive $3m in funding to develop a safe, inexpensive, and non-invasive prenatal diagnostic test.

                                Professor Scott Mabury: 'Plucking Solutions Out of Thin Air'

                                Professor Scott Mabury's research into perfluorinated acids have led to national policy changes on products that put their precursors into the air. He spoke with Research2Reality about these airborne pollutants.

                                “They were waste products that (neither) industry nor government knew were there, so they didn’t know to regulate them,?say Mabury. “We discovered them in the atmosphere, worked them back to where they came from.?/p>

                                Simulating climate change in the lab

                                Professors Jessica D’eon, Kristine Quinlan and Scott Browning, alongside Postdoctoral Fellow Jennifer Faust (Abbatt Group), created a first-year chemistry laboratory meant to improve students?fundamental understanding of greenhouse gases. They're featured in the Varsity this week.

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                                Optimizing NMR Methods for Structure Elucidation: Characterizing Natural Products and Other Organic Compounds
                                This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the ...

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